Just upgraded my personal instance to v5.0.0-beta.1.
For the most part, I think the new layout is okay but not great. I really dislike the forced horizontal scrolling when clicking on a post to view when using the advanced web interface. I think some of that could be negated if the search field and instance information didn't have its own dedicated column.
The search field *ought* to be in the first column and the server information could be an icon link that opens a modal.
I have made the custom CSS available on Codeberg at: https://codeberg.org/qlp/mastodon-custom-css